Phenotypes Associated with This Genotype

Genotype
MGI:3835859

• Allelic Composition: Grin1^tm1Rsp/Grin1^tm1Rsp; Tg(Slc6a3-icre)9075Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:139693 )

• mice that were previously conditioned to associate a certain cage environment with cocaine do not reinstate their cocaine-seeking behavior when administered the drug after a 16 day extinction phase

nervous system

abnormal glutamate-mediated receptor currents ( J:139693 )

• basal glutamate-mediated receptor currents are enhanced in these mice

• cocaine-induced synaptic strengthening in the ventral tegmental area does not occur in these mice

abnormal AMPA-mediated synaptic currents ( J:139693 )

• a higher occurrence of spontaneous AMPA excitatory postsynaptic currents occurs in the ventral tegmental area

abnormal NMDA-mediated synaptic currents ( J:139693 )

• NMDA-mediated excitatory postsynaptic currents are completely abolished in the ventral tegmental area of these mice