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Phenotypes Associated with This Genotype
Genotype
MGI:3835822
Allelic
Composition
Tg(Dspp-TGFB1)3Kul/?
Genetic
Background
FVB/N-Tg(Dspp-TGFB1)3Kul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dspp-TGFB1)3Kul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

skeleton
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

craniofacial
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

growth/size/body
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dentin dysplasia DOID:701 OMIM:125400
OMIM:125420
J:118918


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory