Mouse Genome Informatics
tg
    Tg(Dspp-TGFB1)3Kul/?
FVB/N-Tg(Dspp-TGFB1)3Kul
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

craniofacial
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

growth/size/body
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Dentin Dysplasia, Type I; DTDP1 125400 J:118918
Dentin Dysplasia, Type II 125420 J:118918