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Phenotypes Associated with This Genotype
Genotype
MGI:3835811
Allelic
Composition
Tg(Dspp-TGFB1)3Kul/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dspp-TGFB1)3Kul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• dentin is abnormally mineralized
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• the enamel of molars has a pitted appearance
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• enamel lacks the rod-like that help characterize the enamel-dentin junction

skeleton
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• dentin is abnormally mineralized
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• the enamel of molars has a pitted appearance
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• enamel lacks the rod-like that help characterize the enamel-dentin junction

growth/size/body
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• dentin is abnormally mineralized
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• the enamel of molars has a pitted appearance
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• enamel lacks the rod-like that help characterize the enamel-dentin junction


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory