Phenotypes Associated with This Genotype

Genotype
MGI:3835454

• Allelic Composition: Tg(H2KmPCC)2939Stoe/?; Tg(TcraTcrbAD10)1Hed/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:92997 )

• the number of CD4 single-positive thymocytes are severely reduced in these mice

• peripheral CD4⁺ T cells are reduced from 41% of lymph node cells to 14%

abnormal immune tolerance ( J:92997 )

• negative selection of transgenic T cells leads to diminished CD4 T cells in the periphery

• apoptotic cells resulting from negative selection are found at the cortico-medullary and medullary portions of the thymus

abnormal T cell anergy ( J:92997 )

• T cells that escape central tolerance are able to respond to pigeon cytochrome-c but 10 times as much protein is needed to get a comparable response to Tg(TcrAND)53Hed transgenic

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:92997 )

• the number of CD4 single-positive thymocytes are severely reduced in these mice

• peripheral CD4⁺ T cells are reduced from 41% of lymph node cells to 14%