Phenotypes Associated with This Genotype

Genotype
MGI:3835418

• Allelic Composition: Grin1^tm1Rpa/Grin1^tm1.1Rpa; Slc6a3^tm1(cre)Xz/Slc6a3⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:145468 )

• mice lack the NMDAR component of the excitatory postsynaptic current (EPSC) in dopaminergic neurons unlike in wild-type mice

• AMPA-evoked EPSCs are increased compared to wild-type mice

• however, NMDAR-mediated EPSCs in non-dopaminergic neurons are normal

reduced long-term potentiation ( J:145468 )

• absent in dopaminergic neurons

abnormal miniature excitatory postsynaptic currents ( J:145468 )

• miniature excitatory postsynaptic current (EPSC) are increased in amplitude and frequency compared to in similarly treated wild-type mice that is identical to the increase observed in mice treated with cocaine

increased miniature excitatory postsynaptic current amplitude ( J:145468 )

increased miniature excitatory postsynaptic current frequency ( J:145468 )

behavior/neurological

abnormal behavioral response to addictive substance ( J:145468 )

• 21 days after cocaine withdrawal mice fail to exhibit significant enhancement of behavioral sensitization

• however, mice exhibit normal locomotor-stimulating effects of drugs

impaired conditioned place preference behavior ( J:145468 )

• mice fail to exhibit conditioned place preference for cocaine

• however, mice exhibit normal conditioned place aversion to naloxone