Phenotypes Associated with This Genotype

Genotype
MGI:3835376

• Allelic Composition: Tg(AlbLCAT)1Jdm/0; Tg(APOA1)1Rub/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128254 )

N • despite being fed an atherogenic diet, mice exhibit no change in total cholesterol, triglyceride and HDL-cholesterol levels compared to similarly treated wild-type mice

increased circulating cholesterol level ( J:121992 )

• up to 4.2-fold compared to in Tg(APOA1)1Rub mice

increased circulating HDL cholesterol level ( J:121992 )

• 2-fold compared to in Tg(AlbLCAT)1Jdm or Tg(APOA1)1Rub mice

increased circulating LDL cholesterol level ( J:121992 )

increased circulating VLDL cholesterol level ( J:121992 )

cardiovascular system

increased susceptibility to atherosclerosis ( J:128254 )

• atherosclerotic lesions are 3-fold larger than in Tg(APOA1)1Rub mice