Phenotypes Associated with This Genotype

Genotype
MGI:3835358

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Tg(NES-TVA)J12Ech/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 40% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice

neoplasm

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 35 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 10 grade II (similar to human oligodendroglioma) and 12 grade III (similar to anaplastic oligodendroglioma)

nervous system

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 35 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 10 grade II (similar to human oligodendroglioma) and 12 grade III (similar to anaplastic oligodendroglioma)