Phenotypes Associated with This Genotype

Genotype
MGI:3835329

• Allelic Composition: Cux1^tm1Ejn/Cux1^tm1Ejn; Cys1^cpk/Cys1^cpk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney cyst ( J:142805 )

• mice develop kidney cysts at the same frequency as in Cys1^cpk homozygotes but cysts are larger in size

• mice exhibit an increase in the number of advanced stage cysts compared to in Cys1^cpk homozygotes

• cysts are primarily restricted to the collecting ducts with few proximal tubule cysts

• proliferation and apoptosis of cystic kidneys is increased compared to in Cys1^cpk homozygotes

enlarged kidney ( J:142805 )

• P10, kidneys are larger than in Cys1^cpk homozygotes

increased kidney weight ( J:142805 )

• at P3 and P10, kidney weight to body weight ratio is larger than in Cys1^cpk homozygotes

homeostasis/metabolism

increased blood urea nitrogen level ( J:142805 )

• compared to in Cys1^cpk homozygotes at P10

growth/size/body

kidney cyst ( J:142805 )

• mice develop kidney cysts at the same frequency as in Cys1^cpk homozygotes but cysts are larger in size

• mice exhibit an increase in the number of advanced stage cysts compared to in Cys1^cpk homozygotes

• cysts are primarily restricted to the collecting ducts with few proximal tubule cysts

• proliferation and apoptosis of cystic kidneys is increased compared to in Cys1^cpk homozygotes

enlarged kidney ( J:142805 )

• P10, kidneys are larger than in Cys1^cpk homozygotes

increased kidney weight ( J:142805 )

• at P3 and P10, kidney weight to body weight ratio is larger than in Cys1^cpk homozygotes