Phenotypes Associated with This Genotype

Genotype
MGI:3835111

• Allelic Composition: Tg(CD8aCD8b)57Scr/?
• Genetic Background: B6;SJL-Tg(CD8aCD8b)57Scr/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal effector T cell morphology ( J:92994 )

• 8-9% of splenocytes express human CD8alpha

• about 80% express human CD8alphaCD8beta heterodimers while about 20% express CD8alpha-alpha homodimers

• either CD4⁺ or CD8⁺ T cells can express the human CD8 complex in the periphery

abnormal cytotoxic T cell physiology ( J:92994 )

• expression of human CD8 allows for effector cell function against target cells presenting viral peptide on human HLA-A2 complexes

• this cytolytic effector function is primarily carried out by T cells expressing both mouse and human CD8 complexes

• the presence of the human CD8 co-receptor does not interfere with the ability of T cells to recognize mouse MHC

hematopoietic system

abnormal effector T cell morphology ( J:92994 )

• 8-9% of splenocytes express human CD8alpha

• about 80% express human CD8alphaCD8beta heterodimers while about 20% express CD8alpha-alpha homodimers

• either CD4⁺ or CD8⁺ T cells can express the human CD8 complex in the periphery

abnormal cytotoxic T cell physiology ( J:92994 )

• expression of human CD8 allows for effector cell function against target cells presenting viral peptide on human HLA-A2 complexes

• this cytolytic effector function is primarily carried out by T cells expressing both mouse and human CD8 complexes

• the presence of the human CD8 co-receptor does not interfere with the ability of T cells to recognize mouse MHC