Phenotypes Associated with This Genotype

Genotype
MGI:3835052

• Allelic Composition: H2^u/H2^u; Tg(TCRA)B1Jg/0; Tg(TCRB)C14Jg/0
• Genetic Background: B10.PL-H2^u H2-T18^a/(73NS)Sn-Tg(TCRA)B1Jg Tg(TCRB)C14Jg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:92992 )

• the ratio of double negative to double-positive thymocytes is significantly higher (0.483) in these mice than in controls (0.016)

• the ratio of single-positive (both CD4⁺ and CD8⁺) thymocytes to double-positive thymocytes is significantly increased

increased T cell derived lymphoma incidence ( J:92992 )

• 21.9 % of mice develop lymphoma characterized by CD8⁺CD4^hi-low T cells

• the lymphoma is metastatic and transplantable

• the lymphoma is not found in mice younger than 80 days of age and occurs with equal frequency to male and female mice

abnormal double-negative T cell morphology ( J:92992 )

• a greater proportion of the double-negative thymocytes present in E16 and E17 thymi are in the most mature (c-kit^-CD44^-CD25^-) stage compared to controls

increased double-negative T cell number ( J:92992 )

• double-negative thymocyte numbers are increased to 11.7% of all thymocytes from 1.2% in controls

• the absolute number of double-negative thymocytes is increased over wild-type and is twice that found in Tg(TCRA)B1Jg transgenic mice

abnormal double-positive T cell morphology ( J:92992 )

• the appearance of double-positive T cells in the thymus first occurs on E16 compared to E17 for controls

decreased double-positive T cell number ( J:92992 )

• the appearance of double-positive T cells in the thymus first occurs on E16 compared to E17 for controls

increased CD4-positive, alpha-beta T cell number ( J:92992 )

• the percentage and absolute number of single-positive CD4 thymocytes is increased

absent gamma-delta T cells ( J:92992 )

• gamma-delta T cells are not detected in the thymus of E18 mice

neoplasm

increased T cell derived lymphoma incidence ( J:92992 )

• 21.9 % of mice develop lymphoma characterized by CD8⁺CD4^hi-low T cells

• the lymphoma is metastatic and transplantable

• the lymphoma is not found in mice younger than 80 days of age and occurs with equal frequency to male and female mice

hematopoietic system

abnormal thymus cell ratio ( J:92992 )

• the ratio of double negative to double-positive thymocytes is significantly higher (0.483) in these mice than in controls (0.016)

• the ratio of single-positive (both CD4⁺ and CD8⁺) thymocytes to double-positive thymocytes is significantly increased

increased T cell derived lymphoma incidence ( J:92992 )

• 21.9 % of mice develop lymphoma characterized by CD8⁺CD4^hi-low T cells

• the lymphoma is metastatic and transplantable

• the lymphoma is not found in mice younger than 80 days of age and occurs with equal frequency to male and female mice

abnormal double-negative T cell morphology ( J:92992 )

• a greater proportion of the double-negative thymocytes present in E16 and E17 thymi are in the most mature (c-kit^-CD44^-CD25^-) stage compared to controls

increased double-negative T cell number ( J:92992 )

• double-negative thymocyte numbers are increased to 11.7% of all thymocytes from 1.2% in controls

• the absolute number of double-negative thymocytes is increased over wild-type and is twice that found in Tg(TCRA)B1Jg transgenic mice

abnormal double-positive T cell morphology ( J:92992 )

• the appearance of double-positive T cells in the thymus first occurs on E16 compared to E17 for controls

decreased double-positive T cell number ( J:92992 )

• the appearance of double-positive T cells in the thymus first occurs on E16 compared to E17 for controls

increased CD4-positive, alpha-beta T cell number ( J:92992 )

• the percentage and absolute number of single-positive CD4 thymocytes is increased

absent gamma-delta T cells ( J:92992 )

• gamma-delta T cells are not detected in the thymus of E18 mice

endocrine/exocrine glands

abnormal thymus cell ratio ( J:92992 )

• the ratio of double negative to double-positive thymocytes is significantly higher (0.483) in these mice than in controls (0.016)

• the ratio of single-positive (both CD4⁺ and CD8⁺) thymocytes to double-positive thymocytes is significantly increased

increased T cell derived lymphoma incidence ( J:92992 )

• 21.9 % of mice develop lymphoma characterized by CD8⁺CD4^hi-low T cells

• the lymphoma is metastatic and transplantable

• the lymphoma is not found in mice younger than 80 days of age and occurs with equal frequency to male and female mice