Phenotypes Associated with This Genotype

Genotype
MGI:3835051

• Allelic Composition: H2^u/H2^u; Tg(TCRB)C14Jg/0
• Genetic Background: B10.PL-H2^u H2-T18^a/(73NS)Sn-Tg(TCRB)C14Jg/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal double-negative T cell morphology ( J:92992 )

• a greater proportion of the double-negative thymocytes present in E16 and E17 thymi are in the most mature (c-kit^-CD44^-CD25^-) stage compared to controls

abnormal double-positive T cell morphology ( J:92992 )

• the appearance of double-positive T cells in the thymus first occurs on E15 compared to E17 for controls

absent gamma-delta T cells ( J:92992 )

• gamma-delta T cells are not detected in the thymus of E18 mice

hematopoietic system

abnormal double-negative T cell morphology ( J:92992 )

• a greater proportion of the double-negative thymocytes present in E16 and E17 thymi are in the most mature (c-kit^-CD44^-CD25^-) stage compared to controls

abnormal double-positive T cell morphology ( J:92992 )

• the appearance of double-positive T cells in the thymus first occurs on E15 compared to E17 for controls

absent gamma-delta T cells ( J:92992 )

• gamma-delta T cells are not detected in the thymus of E18 mice