Phenotypes Associated with This Genotype

Genotype
MGI:3835038

• Allelic Composition: Tg(MGMT)3Bec/Tg(MGMT)3Bec
• Genetic Background: involves: NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:92925 )

• 52% (at 20 umol MNU) and 71% (at 50 umol MNU) of mice develop tumors compared to 87% and 100%, respectively, of wild type mice following repeated exposure to TPA

• 23 weeks after treatment with 20 umol MNU and TPA, mice exhibit 0.9 papillomas per mouse compared to 5.2 per wild-type mouse

• however, development of internal tumors following treatment with MNU and TPA is the same as in wild-type mice

increased incidence of tumors by chemical induction ( J:92925 )

• mice exhibit a slightly higher incidence of DMBA and TPA-induced tumors compared to similarly treated wild-type mice

increased skin papilloma incidence ( J:92925 )

• 23 weeks after treatment with 20 umol MNU and TPA, mice exhibit 0.9 papillomas per mouse compared to 5.2 per wild-type mouse

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:92925 )

• 52% (at 20 umol MNU) and 71% (at 50 umol MNU) of mice develop tumors compared to 87% and 100%, respectively, of wild type mice following repeated exposure to TPA

• 23 weeks after treatment with 20 umol MNU and TPA, mice exhibit 0.9 papillomas per mouse compared to 5.2 per wild-type mouse

• however, development of internal tumors following treatment with MNU and TPA is the same as in wild-type mice

increased incidence of tumors by chemical induction ( J:92925 )

• mice exhibit a slightly higher incidence of DMBA and TPA-induced tumors compared to similarly treated wild-type mice

integument

increased skin papilloma incidence ( J:92925 )

• 23 weeks after treatment with 20 umol MNU and TPA, mice exhibit 0.9 papillomas per mouse compared to 5.2 per wild-type mouse