Phenotypes Associated with This Genotype

Genotype
MGI:3834935

• Allelic Composition: B2m^tm1Jae/B2m^tm1Jae; Tg(LckNotch1)9Erob/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD8-positive, alpha-beta T cell number ( J:93005 )

• mice have 2-fold more mature single-positive CD8 thymocytes than wild-type mice and over a 1000-fold more than fold in B2m^tm1Jae homozygote controls

• in the periphery, CD8⁺ T cells make up 2% of the lymph node population compared to less than 0.1% for B2m^tm1Jae homozygote controls

lymph node hypoplasia ( J:93005 )

• lymph node cellularity is 25% that of controls, with a normal ratio between CD4⁺ and CD8⁺ T cells

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:93005 )

• mice have 2-fold more mature single-positive CD8 thymocytes than wild-type mice and over a 1000-fold more than fold in B2m^tm1Jae homozygote controls

• in the periphery, CD8⁺ T cells make up 2% of the lymph node population compared to less than 0.1% for B2m^tm1Jae homozygote controls