Phenotypes Associated with This Genotype

Genotype
MGI:3834934

• Allelic Composition: Tg(LckNotch1)9Erob/?
• Genetic Background: involves: C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:93005 )

• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production

increased T cell derived lymphoma incidence ( J:93005 )

• older mice can develop thymomas consisting of thymocytes with a CD8⁺CD4^lowTCR^low morphology

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93005 )

• thymocyte development is skewed towards development into the CD8 T cell lineage

• mutant bone marrow can support CD8 T cell development when transferred to class I MHC or class II MHC-deficient host mice

• however, mutant bone marrow can not support CD8 T cell development in hosts deficient for both class I and class II MHC

decreased CD4-positive, alpha-beta T cell number ( J:93005 )

• while decreases in CD4 single positive thymocyte number are inconsistent, kinetic studies demonstrate a 5-fold decrease in CD4 single-positive thymocyte production compared to control

increased CD8-positive, alpha-beta T cell number ( J:93005 )

• there is a 10-fold increase in the number and percentage of mature CD8 single-positive thymocytes compared to controls

• production of these single-positive CD8 thymocytes is increased 3-fold

neoplasm

increased T cell derived lymphoma incidence ( J:93005 )

• older mice can develop thymomas consisting of thymocytes with a CD8⁺CD4^lowTCR^low morphology

hematopoietic system

abnormal thymus cell ratio ( J:93005 )

• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production

increased T cell derived lymphoma incidence ( J:93005 )

• older mice can develop thymomas consisting of thymocytes with a CD8⁺CD4^lowTCR^low morphology

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93005 )

• thymocyte development is skewed towards development into the CD8 T cell lineage

• mutant bone marrow can support CD8 T cell development when transferred to class I MHC or class II MHC-deficient host mice

• however, mutant bone marrow can not support CD8 T cell development in hosts deficient for both class I and class II MHC

decreased CD4-positive, alpha-beta T cell number ( J:93005 )

• while decreases in CD4 single positive thymocyte number are inconsistent, kinetic studies demonstrate a 5-fold decrease in CD4 single-positive thymocyte production compared to control

increased CD8-positive, alpha-beta T cell number ( J:93005 )

• there is a 10-fold increase in the number and percentage of mature CD8 single-positive thymocytes compared to controls

• production of these single-positive CD8 thymocytes is increased 3-fold

endocrine/exocrine glands

abnormal thymus cell ratio ( J:93005 )

• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production

increased T cell derived lymphoma incidence ( J:93005 )

• older mice can develop thymomas consisting of thymocytes with a CD8⁺CD4^lowTCR^low morphology