Phenotypes Associated with This Genotype

Genotype
MGI:3834902

• Allelic Composition: \Tg(Cd8aCd8b)3Erob/0; \Tg(TcraH-Y,TcrbH-Y)71Vbo/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93004 )

• there is a 5-6 fold increase in the thymocyte population that is CD4^- CD8.2⁺ (i.e. positive for the endogenous CD8 complex)

• among thymocytes expressing the transgenic TCR, the skewing of the CD4:CD8 ratio is 1:50

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

increased CD8-positive, alpha-beta T cell number ( J:93004 )

• the CD8 transgene further skews differentiation of T cells expressing the transgenic TCR into the CD8 T cell lineage

abnormal CD4-positive, alpha beta T cell morphology ( J:93004 )

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93004 )

• there is a 5-6 fold increase in the thymocyte population that is CD4^- CD8.2⁺ (i.e. positive for the endogenous CD8 complex)

• among thymocytes expressing the transgenic TCR, the skewing of the CD4:CD8 ratio is 1:50

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

increased CD8-positive, alpha-beta T cell number ( J:93004 )

• the CD8 transgene further skews differentiation of T cells expressing the transgenic TCR into the CD8 T cell lineage

abnormal CD4-positive, alpha beta T cell morphology ( J:93004 )

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene