Phenotypes Associated with This Genotype

Genotype
MGI:3834901

• Allelic Composition: Tg(Cd8aCd8b)3Erob/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93004 )

• transgenic expression of the CD8 complex leads to almost all peripheral T cells expressing CD8 either alone as CD8⁺ T cells or as double positive CD4⁺CD8⁺ T cells

• endogenous expression of CD8 genes does not occur in CD4⁺CD8⁺ T cells but does occur in single positive CD8⁺ T cells

decreased double-negative T cell number ( J:93004 )

• the double negative population in the thymus is severely reduced due to expression of the transgenic CD8 complex

abnormal double-positive T cell morphology ( J:93004 )

• the single-positive CD4 T cell population in the periphery is replaced by a CD4⁺CD8⁺ population

• the double-positive population in the thymus is greatly enhanced

decreased CD4-positive, alpha-beta T cell number ( J:93004 )

• the single positive CD4 T cell population in the thymus and in the periphery is virtually absent due to transgenic expression of CD8

increased CD8-positive, alpha-beta T cell number ( J:93004 )

• almost all peripheral T cells express CD8 with over half also expressing CD4

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93004 )

• transgenic expression of the CD8 complex leads to almost all peripheral T cells expressing CD8 either alone as CD8⁺ T cells or as double positive CD4⁺CD8⁺ T cells

• endogenous expression of CD8 genes does not occur in CD4⁺CD8⁺ T cells but does occur in single positive CD8⁺ T cells

decreased double-negative T cell number ( J:93004 )

• the double negative population in the thymus is severely reduced due to expression of the transgenic CD8 complex

abnormal double-positive T cell morphology ( J:93004 )

• the single-positive CD4 T cell population in the periphery is replaced by a CD4⁺CD8⁺ population

• the double-positive population in the thymus is greatly enhanced

decreased CD4-positive, alpha-beta T cell number ( J:93004 )

• the single positive CD4 T cell population in the thymus and in the periphery is virtually absent due to transgenic expression of CD8

increased CD8-positive, alpha-beta T cell number ( J:93004 )

• almost all peripheral T cells express CD8 with over half also expressing CD4