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Phenotypes Associated with This Genotype
Genotype
MGI:3834848
Allelic
Composition
Atrxtm1Rjg/Y
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (72 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• pericellular varicosities in the retina are significantly reduced compared to in wild-type mice indicating a disturbance in the dopaminergic network (J:145002)
• pericellular varicosities in the retina are significantly reduced compared to in wild-type mice indicating a disturbance in the dopaminergic network (J:145002)
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)
• cellularity is reduced 15% while the number of ganglion cells is normal (J:145002)
• cellularity is reduced 15% while the number of ganglion cells is normal (J:145002)
• cellularity is reduced 25% with the numbers of Muller, bipolar and photoreceptor cells are normal (J:145002)
• cellularity is reduced 25% with the numbers of Muller, bipolar and photoreceptor cells are normal (J:145002)
• the b-wave is reduced 30% at the five highest light intensities tested compared to in wild-type mice (J:145002)
• oscillatory potentials are reduced in amplitude at multiple light intensities compared to in wild-type mice (J:145002)
• however, the a-wave is normal (J:145002)
• the b-wave is reduced 30% at the five highest light intensities tested compared to in wild-type mice (J:145002)
• oscillatory potentials are reduced in amplitude at multiple light intensities compared to in wild-type mice (J:145002)
• however, the a-wave is normal (J:145002)

nervous system
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory