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Phenotypes Associated with This Genotype
Genotype
MGI:3834737
Allelic
Composition		 Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53+
Tg(Wap-cre)11738Mam/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Mak mutation (1 available); any Brca1 mutation (115 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:90512 )
• about 80% develop acinar adenocarcenomas

integument
increased mammary adenocarcinoma incidence ( J:90512 )
• about 80% develop acinar adenocarcenomas

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:90512 )
• about 80% develop acinar adenocarcenomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory