Phenotypes Associated with This Genotype

Genotype
MGI:3834734

• Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak; Chek2^tm1Mak/Chek2^tm1Mak; Tg(Lck-cre)548Jxm/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

immune system

immune system phenotype ( J:90512 )

N • complete thymocyte restoration

N • T cell numbers in the periphery are restored

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

cellular

cellular phenotype ( J:90512 )

N • resistant to gamma irradiation

N • restoration of normal cell cycle arrest of T cells when stimulated with antibody to CD3e or CD3 and Il2

chromosomal instability ( J:90512 )

• increased frequency

neoplasm

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

hematopoietic system

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus