Phenotypes Associated with This Genotype

Genotype
MGI:3834730

• Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak; Tg(Lck-cre)548Jxm/?; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

mortality/aging

premature death ( J:90512 )

• most mice with thymic lymphomas are moribund or die by 3 months of age

cellular

chromosomal instability ( J:63282 )

• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

spontaneous chromosome breakage ( J:63282 )

immune system

immune system phenotype ( J:63282 )

N • thymus cellularity restored

N • T cell numbers in lymph nodes are improved

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

neoplasm

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

hematopoietic system

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency