Phenotypes Associated with This Genotype

Genotype
MGI:3834729

• Allelic Composition: Brca1^tm2Mak/Brca1^tm2Mak; Tg(Lck-cre)548Jxm/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:63282 )

• reduced proliferation when stimulated with monoclonal antibody to CD3e

abnormal T cell number ( J:63282 )

increased double-negative T cell number ( J:63282 )

• increased proportion of double negative thymocytes

• absolute number of double negative thymocytes is normal

decreased double-positive T cell number ( J:63282 )

• less than 10% of number in controls

decreased single-positive T cell number ( J:63282 )

• less than 10% of number in controls

abnormal immune system organ morphology ( J:63282 )

decreased thymocyte number ( J:63282 )

• 90% reduction in thymocyte number

cellular

abnormal cell cycle checkpoint function ( J:63282 )

• fewer T cells entering S phase

abnormal cell death ( J:63282 )

• reduced viability of thymocytes in culture

• reduced survival of T cells when stimulated with monoclonal antibody to CD3e

increased cellular sensitivity to gamma-irradiation induced cell death ( J:63282 )

• increased thymocyte sensitivity of gamma-irradiation

decreased T cell proliferation ( J:63282 )

• reduced proliferation when stimulated with monoclonal antibody to CD3e

neoplasm

increased tumor incidence ( J:90512 )

• only about 12% with tumors

• most tumors are peripheral rather than thymic

hematopoietic system

decreased T cell proliferation ( J:63282 )

• reduced proliferation when stimulated with monoclonal antibody to CD3e

abnormal T cell number ( J:63282 )

decreased thymocyte number ( J:63282 )

• 90% reduction in thymocyte number

increased double-negative T cell number ( J:63282 )

• increased proportion of double negative thymocytes

• absolute number of double negative thymocytes is normal

decreased double-positive T cell number ( J:63282 )

• less than 10% of number in controls

decreased single-positive T cell number ( J:63282 )

• less than 10% of number in controls

endocrine/exocrine glands

decreased thymocyte number ( J:63282 )

• 90% reduction in thymocyte number

homeostasis/metabolism

increased cellular sensitivity to gamma-irradiation induced cell death ( J:63282 )

• increased thymocyte sensitivity of gamma-irradiation