Phenotypes Associated with This Genotype

Genotype
MGI:3834631

• Allelic Composition: Kdm1a^tm1.2Tche/Kdm1a^tm1.2Tche
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:144527 )

• all mice are resorbed by E7.5

embryo

failure to gastrulate ( J:144527 )

embryonic growth arrest ( J:144527 )

• development arrests at or before E5.5 with the egg cylinder failing to elongate and undergo gastrulation

absent egg cylinders ( J:144527 )

cellular

increased apoptosis ( J:144527 )

• in cultured cells