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Phenotypes Associated with This Genotype
Genotype
MGI:3834588
Allelic
Composition		 Cd14tm1Smg/Cd14tm1Smg
Genetic
Background		 B6.129S1-CD14tm1Smg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14tm1Smg mutation (0 available); any Cd14 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:127072 )
• eight hours after infection with E. coli, mice have 10-fold lower bacterial counts in the blood as do infection wild-type controls
• the bacterial resistance is abolished when mice are made neutropenic by cyclophosphamide treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory