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Phenotypes Associated with This Genotype
Genotype
MGI:3834579
Allelic
Composition
Slitrk1tm1Jaru/Slitrk1tm1Jaru
Genetic
Background
B6.129P2-Slitrk1tm1Jaru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slitrk1tm1Jaru mutation (0 available); any Slitrk1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected homozygotes are found at weaning
• no further losses were detected during behavioral testing
• fewer than expected homozygotes are found at weaning

growth/size/body
• males weigh about 11% less than wild-type littermates
• no significant difference in weight is detected for females

behavior/neurological
• spend more time floating immobile in a forced swim test and more time immobile in a tail suspension test
• mice spend less time in the open arms and have fewer entries into the open arms in an elevated plus maze
• treatment with clonidine attenuates the increase in anxiety related behaviors
• increase in freezing in response to the context alone in a fear conditioning test
• pronounced decrease in locomotor activity in a variety of assays
• activity in the home cage is reduced in the light phase but not in the dark phase

nervous system
N
• no anatomical or histological defects are detected in the brain
• norepinephrine levels are significantly increased in the prefrontal cortex
• 3-methoxy-4-hydroxyphenylglycol (MHPG, a metabolite of norepinephrine) levels are elevated in the nucleus accumbens
• choline and acteylcholine levels in the striatum are reduced
• norepinephrine levels are significantly increased in the prefrontal cortex
• 3-methoxy-4-hydroxyphenylglycol (MHPG, a metabolite of norepinephrine) levels are elevated in the nucleus accumbens

homeostasis/metabolism
• norepinephrine levels are significantly increased in the prefrontal cortex
• 3-methoxy-4-hydroxyphenylglycol (MHPG, a metabolite of norepinephrine) levels are elevated in the nucleus accumbens

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Gilles de la Tourette syndrome DOID:11119 OMIM:137580
J:145441


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory