Phenotypes for Cd14 Tlr4 MGI:3834574 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd14^tm1Smg/Cd14^tm1Smg Tlr4^Lps-d/Tlr4^Lps-d
Genetic Background	C3.129S1-CD14^tm1Smg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14^tm1Smg mutation (0 available); any Cd14 mutation (23 available)
Tlr4^Lps-d mutation (7 available); any Tlr4 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:116691 )

• macrophages fail to respond to LPS even at the very high doses that stimulate macrophages homozygote for just the CD14^tm1Smg null allele

decreased tumor necrosis factor secretion ( J:116691 )

• no TNF is produced by macrophages in response to LPS stimulation

hematopoietic system

abnormal macrophage physiology ( J:116691 )

• macrophages fail to respond to LPS even at the very high doses that stimulate macrophages homozygote for just the CD14^tm1Smg null allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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