Analysis Tools
mortality/aging
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• mice are resistant to gram-negative E. coli bacterial infection with 100% survivability when given an inoculum lethal to control mice
• four times the lethal dose of E. coli leads to death in about half the mutant mice, and all the mice die at six times the lethal dose of E. coli
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immune system
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• mice release substantially less IL-6 into their bloodstream after injection with LPS or when infected with E. coli
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• mice release substantially less TNF into their bloodstream after injection with LPS or when infected with E. coli
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• 100-1000 fold more LPS is needed by monocytes to secrete the same amount of IL-6 as in LPS-dosed controls
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• 100-1000 fold more LPS is needed by monocytes to secrete the same amount of TNF as in LPS-dosed controls
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• none of the mice die when injected with a dose of LPS that causes a 100% lethality in wild-type controls
• when given 10 times the lethal dose of LPS, some of the mutant mice demonstrate signs of mild endotoxemia
• only in mice given a LPS sensitizer and 10 times the lethal dose do mice exhibit some lethality
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• 27-fold lower level of bacteria are found in the blood of these infected mutant mice compared to controls
• in mice receiving six times the lethal dose of E. coli, there are 35-fold fewer bacteria in the blood than in controls 7 hour after infection
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• mice are resistant to gram-negative E. coli bacterial infection with 100% survivability when given an inoculum lethal to control mice
• four times the lethal dose of E. coli leads to death in about half the mutant mice, and all the mice die at six times the lethal dose of E. coli
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homeostasis/metabolism
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• mice release substantially less IL-6 into their bloodstream after injection with LPS or when infected with E. coli
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• mice release substantially less TNF into their bloodstream after injection with LPS or when infected with E. coli
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