Phenotypes for Eaf2 MGI:3834182 MGI Mouse

premature death ( J:145228 )

• mice begin to die at 4 months of age with 32% mortality by 16 months

• however, beyond 16 months sudden death is rate

increased tumor incidence ( J:145228 )

• in 82% of mice compared to 5% of wild-type mice

increased prostate intraepithelial neoplasia incidence ( J:145228 )

• 8 of 15 mice exhibit prostate intraepithelial neoplasia that does not develop into invasive prostate cancer

increased skin tumor incidence ( J:145228 )

• in 5% of mice

increased hepatocellular carcinoma incidence ( J:145228 )

• in 32% of mice

increased B cell derived lymphoma incidence ( J:145228 )

• 45% of mice develop lymphomas that are found in the spleen, liver, lung, kidney, intestine, abdomen, and skin

increased lung adenocarcinoma incidence ( J:145228 )

• in 53% of mice

abnormal prostate gland morphology ( J:145228 )

• at 6 months, 11 of 13 mice exhibit prostate abnormalities including a more opaque-whitish appearance compared to in wild-type mice

abnormal prostate gland epithelium morphology ( J:145228 )

• the ventral, lateral and anterior, but not dorsal, prostate display hyperplasia and hypertrophy with some severe dysplasia

• epithelium cells exhibit a 4.5- to 5.7-fold increase in proliferation compared to in wild-type mice

• epithelial cell size increases 33% compared to in wild-type mice

increased prostate gland weight ( J:145228 )

• at 6 months, ventral and dorsal prostate lobes exhibit a 20% to 30% increase in weight

increased prostate intraepithelial neoplasia incidence ( J:145228 )

• 8 of 15 mice exhibit prostate intraepithelial neoplasia that does not develop into invasive prostate cancer

abnormal heart morphology ( J:145228 )

• at 6 to 12 months, cardiac cell density is decreased 20% compared to in wild-type mice

enlarged heart ( J:145228 )

• at 6 to 12 months, 39% of mice exhibit enlarged hearts

abnormal prostate gland morphology ( J:145228 )

• at 6 months, 11 of 13 mice exhibit prostate abnormalities including a more opaque-whitish appearance compared to in wild-type mice

abnormal prostate gland epithelium morphology ( J:145228 )

• the ventral, lateral and anterior, but not dorsal, prostate display hyperplasia and hypertrophy with some severe dysplasia

• epithelium cells exhibit a 4.5- to 5.7-fold increase in proliferation compared to in wild-type mice

• epithelial cell size increases 33% compared to in wild-type mice

increased prostate gland weight ( J:145228 )

• at 6 months, ventral and dorsal prostate lobes exhibit a 20% to 30% increase in weight

increased prostate intraepithelial neoplasia incidence ( J:145228 )

• 8 of 15 mice exhibit prostate intraepithelial neoplasia that does not develop into invasive prostate cancer

increased skin tumor incidence ( J:145228 )

• in 5% of mice

enlarged heart ( J:145228 )

• at 6 to 12 months, 39% of mice exhibit enlarged hearts

increased lung adenocarcinoma incidence ( J:145228 )

• in 53% of mice

increased hepatocellular carcinoma incidence ( J:145228 )

• in 32% of mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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