Phenotypes Associated with This Genotype

Genotype
MGI:3834166

• Allelic Composition: Rb1^tm1Brd/Rb1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pheochromocytoma incidence ( J:79016 )

• seen in most mice

increased pituitary adenohypophysis tumor incidence ( J:79016 )

• some mice develop tumors of the pituitary anterior lobe

increased pituitary melanotroph tumor incidence ( J:79016 )

• all mice develop melanotroph tumors of the pituitary

increased thyroid C-cell carcinoma incidence ( J:79016 )

• most mice develop C cell thyroid carcinomas

nervous system

increased pituitary adenohypophysis tumor incidence ( J:79016 )

• some mice develop tumors of the pituitary anterior lobe

increased pituitary melanotroph tumor incidence ( J:79016 )

• all mice develop melanotroph tumors of the pituitary

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:79016 )

• seen in most mice

increased pituitary adenohypophysis tumor incidence ( J:79016 )

• some mice develop tumors of the pituitary anterior lobe

increased pituitary melanotroph tumor incidence ( J:79016 )

• all mice develop melanotroph tumors of the pituitary

increased thyroid C-cell carcinoma incidence ( J:79016 )

• most mice develop C cell thyroid carcinomas