Analysis Tools
mortality/aging
| N |
• unlike mice homozygous for a null allele, mice are viable
|
nervous system
|
• developmental delay in peripheral nerve myelination with most Schwann cells remaining in a promyelin configuration during the week of life
• initiation of myelination by most Schwann cells occurs between P16 and P32 compared to P8 in heterozygous controls
• myelination is also delayed during nerve regeneration following crush injury of the sciatic nerve
|
respiratory system
| N |
• unlike mice homozygous for a null allele, mice do not develop respiratory distress
|
