Phenotypes for Rab27a Rab27b MGI:3834158 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rab27a^ash/Rab27a^ash Rab27b^tm1Tiz/Rab27b^tm1Tiz
Genetic Background	involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab27a^ash mutation (3 available); any Rab27a mutation (147 available)
Rab27b^tm1Tiz mutation (1 available); any Rab27b mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system physiology ( J:145238 )

• mice exhibit minor defects in reproduction

endocrine/exocrine glands

abnormal corticotroph morphology ( J:145238 )

• ACTH-containing granules are not polarized to the plasma membrane as in wild-type cells

• however, evoked ACTH secretion is normal

nervous system

abnormal corticotroph morphology ( J:145238 )

• ACTH-containing granules are not polarized to the plasma membrane as in wild-type cells

• however, evoked ACTH secretion is normal

pigmentation

diluted coat color ( J:145238 )

integument

diluted coat color ( J:145238 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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