Phenotypes Associated with This Genotype

Genotype
MGI:3833851

• Allelic Composition: Park7^tm1Cai/Park7^tm1Cai
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:141628 )

• mice weigh less than controls starting around 1 year in age

behavior/neurological

abnormal motor learning ( J:141628 )

• 16-month old mice have enhanced motor learning over 3 days with 62.3% increase in latency time to fall compared to just a 34.6% increase for wild-type controls

decreased grip strength ( J:141628 )

• mice at 16 months of age, but not 2 months of age, have a significant decrease in foregrip strength

abnormal gait ( J:141628 )

• two month old mice have defects in stride uniformity and hind base displacement

• defects are more severe in two year old mice

short stride length ( J:141628 )

• two-year old mice have a mean decrease in stride length with a mean of 5.35 cm vs. 5.9 for controls

• dopamine treatment failed to increase stride length as it did for wild-type mice

• this defect in stride length is not observed in 2-month mice

decreased locomotor activity ( J:141628 )

• mice at 5 and 14 months of age have decreased activity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 7		DOID:0060370	OMIM:606324	J:141628