Phenotypes Associated with This Genotype

Genotype
MGI:3833842

• Allelic Composition: P2rx7^tm1Lex/P2rx7^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:145020 )

N • no significant differences from controls were seen in spontaneous locomotor activity, in performance in an elevated plus maze, or in novelty suppressed feeding

increased compensatory feeding amount ( J:145020 )

• increased food consumption following a 24 h fast

increased coping response ( J:145020 )

• decreased immobility time in a tail suspension test and forced swim test

immune system

abnormal macrophage physiology ( J:145020 )

• no IL1B release from peritoneal macrophages primed with LPS and then stimulated with BzATP

hematopoietic system

abnormal macrophage physiology ( J:145020 )

• no IL1B release from peritoneal macrophages primed with LPS and then stimulated with BzATP