Phenotypes Associated with This Genotype

Genotype
MGI:3833620

• Allelic Composition: Tg(Lck-Akt1*E40K)E-3Pnt/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144975 )

• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age

neoplasm

increased T cell derived lymphoma incidence ( J:144975 )

• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age

• all mice develop thymic lymphomas by 28 weeks

immune system

increased T cell derived lymphoma incidence ( J:144975 )

• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age

• all mice develop thymic lymphomas by 28 weeks

abnormal T cell differentiation ( J:144975 )

• DN1 thymocyte numbers are increased while DN3 and DN4 thymocyte numbers are decreased compared to in wild-type mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:144975 )

• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age

• all mice develop thymic lymphomas by 28 weeks

abnormal T cell differentiation ( J:144975 )

• DN1 thymocyte numbers are increased while DN3 and DN4 thymocyte numbers are decreased compared to in wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:144975 )

• mice develop thymic lymphomas and are moribund beginning at 5 weeks of age

• all mice develop thymic lymphomas by 28 weeks