Phenotypes Associated with This Genotype

Genotype
MGI:3833565

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor^{tm1(Tcfe2a/Tal1)Xhsu}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:144569 )

• lin ^- kit⁺ Sca-1⁺ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 20- to 40- fold more B cells than controls when cultured under condition supporting lymphopoiesis

abnormal myelopoiesis ( J:144569 )

• lin^- kit⁺ Sca-1⁺ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 10-fold lower percentages and numbers of myeloid lineage cells in vitro than controls

• however, normal number of myeloid cells are produced from myeloid progenitor cells

immune system

abnormal lymphopoiesis ( J:144569 )

• lin ^- kit⁺ Sca-1⁺ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 20- to 40- fold more B cells than controls when cultured under condition supporting lymphopoiesis

abnormal myelopoiesis ( J:144569 )

• lin^- kit⁺ Sca-1⁺ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 10-fold lower percentages and numbers of myeloid lineage cells in vitro than controls

• however, normal number of myeloid cells are produced from myeloid progenitor cells