Phenotypes Associated with This Genotype

Genotype
MGI:3833426

• Allelic Composition: Gdi1^tm1Toni/Y
• Genetic Background: either: B6.129S7-Gdi1^tm1Toni or (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * DBA/2)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:79454 )

♂ • impaired trace fear conditioning

♂ • however, delay fear conditioning behavior is similar to controls

abnormal spatial working memory ( J:79454 )

♂ • in a radial maze after training mice perform just barely above the chance level unlike wild-type controls which after training show nearly perfect performance

decreased aggression towards mice ( J:79454 )

♂ • decrease in aggression in a resident intruder assay

♂ • mice spend more time sniffing the snout end of intruders compared to controls

nervous system

abnormal hippocampus CA3 region morphology ( J:79454 )

♂ • in the hilar region of CA3 pyramidal cells appear more scattered

abnormal hippocampal mossy fiber suprapyramidal bundle morphology ( J:79454 )

♂ • increase in the frequency of trilamination of suprapyramidal mossy fibers

abnormal excitatory postsynaptic potential ( J:79454 )

♂ • significant depression of the slope of the field EPSP in the first 5 minutes post tetanus

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79454 )

♂N • despite abnormalities in aggressive behavior, serum testosterone levels are similar to controls

taste/olfaction

taste/olfaction phenotype ( J:79454 )

♂N • despite abnormalities in aggressive behavior, no abnormalities in olfaction are detected