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Phenotypes Associated with This Genotype
Genotype
MGI:3833134
Allelic
Composition		 Itga3tm1Hap/Itga3tm1Hap
Tg(CAG-Bgeo/GFP)21Lbe/?
Tg(SFTPC-rtTA)5Jaw/?
Tg(tetO-cre)1Jaw/?
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Hap mutation (0 available); any Itga3 mutation (52 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-cre)1Jaw mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal pulmonary alveolus epithelial cell morphology ( J:144703 )
• epithelial to mesenchymal transition results from bleomycin-mediated injury of the lung
• only 1.4% of GFP+, epithelium derived cells express mesenchyme markers 17 days after bleomycin injury compared to 7.0% in controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory