Mouse Genome Informatics
tg
    Tg(SOD1*H46R*H48Q)58Dbo/0
involves: C3H/HeJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• astrogliosis is observed in the cortical and hippocampal brain regions, the ventral midbrain, brain stem and spinal cord unlike in wild-type mice
• in the spinal cord of paralyzed mice

behavior/neurological
• at 4 to 6 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:119631