Phenotypes for Tg(Ela2a-Prss1*,-GFP)1Dbs MGI:3832860 MGI Mouse

abnormal pancreatic acinar cell morphology ( J:144663 )

• after 6 months, acinar cells exhibit loss of cell height, enlargement of central lumen, and failure to stain uniformly for the acinar-specific marker amylase unlike wild-type cells

abnormal pancreatic acinar cell physiology ( J:144663 )

• after 6 months, acinar cells exhibit increased proliferation compared to in wild-type cells

pancreas necrosis ( J:144663 )

• at 7 weeks of age, mice develop regions of progressive acinar cell damage with characteristics of necrosis unlike in wild-type mice

• however, duct and islet cells are not effected

abnormal pancreatic acinar cell morphology ( J:144663 )

• after 6 months, acinar cells exhibit loss of cell height, enlargement of central lumen, and failure to stain uniformly for the acinar-specific marker amylase unlike wild-type cells

abnormal pancreatic acinar cell physiology ( J:144663 )

• after 6 months, acinar cells exhibit increased proliferation compared to in wild-type cells

pancreas fibrosis ( J:144663 )

• at 4 to 7 months, 24% of mice exhibit fibrotic inflammation in the pancreas unlike wild-type mice

• at 24 weeks, fibrosis in the form of collagen deposition and pancreatic stellate cell activation is evident unlike in wild-type mice

• at 1 year, 40% of mice exhibit pancreatic fibrosis

chronic pancreas inflammation ( J:144663 )

• pancreatic inflammatory infiltrate is composed of T cells, B cells, and macrophages

• mice older than 6 months exhibit chronic pancreatic inflammatory lesions

increased susceptibility to induced pancreatitis ( J:144663 )

• treatment with cerulein after 1 week produces an inflammatory response in the pancreas unlike in wild-type mice