Phenotypes Associated with This Genotype

Genotype
MGI:3832413

• Allelic Composition: Stat6^tm1Gru/Stat6⁺; Tg(Scgb1a1-Il13)2Eli/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal respiratory system morphology ( J:132385 )

• substantial epithelial fibrosis occurs

abnormal lung morphology ( J:132385 )

• discolored lungs

abnormal lung size ( J:132385 )

• distended lungs

abnormal pulmonary alveolus morphology ( J:132385 )

• alveolar tissue destruction

overexpanded pulmonary alveolus ( J:132385 )

• alveoli are enlarged

abnormal respiratory system physiology ( J:132385 )

• develop airway hyper reactivity

• increased mucus production

respiratory system inflammation ( J:132385 )

• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles

immune system

respiratory system inflammation ( J:132385 )

• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles