Mouse Genome Informatics
hm
    Prlhtm1Taon/Prlhtm1Taon
B6N.129X1-Prlhtm1Taon
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• become significantly heavier by 18 weeks of age when fed a normal chow diet ad libitum
• body weight gain is more prominent when fed a high fat diet ad libitum
• when food intake is restricted to match mean food intake of wild-type controls body weight is not significantly different from wild-type controls
• adult onset obesity
• become significantly heavier when fed a high fat diet compared to wild-type controls

adipose tissue
• increase in both subcutaneous and intraabdominal fat pad masses
• epididymal adipocytes are increased in size

behavior/neurological
N
• no significant difference in home cage activity levels compared to wild-type controls (J:144729)
• seen on both normal chow and high fat diets
• seen at 24 weeks of age but not before 14 weeks of age
• impairment in reduction in food intake following peripheral or central leptin administration
• feeding after a fast is increased at 14 weeks of age

homeostasis/metabolism
N
• no significant difference in oxygen consumption or mean respiratory exchange ratios compared to wild-type controls (J:144729)
• become significantly heavier when fed a high fat diet compared to wild-type controls
• in mice fed a normal chow diet ad libitum
• when food intake is restricted to match mean food intake of wild-type controls glucose tolerance is similar to wild-type controls
• in mice fed a normal chow diet ad libitum
• when food intake is restricted to match mean food intake of wild-type controls insulin sensitivity is similar to wild-type controls
• increase in hepatic triglyceride levels

liver/biliary system
• increase in hepatic triglyceride levels

nervous system
• after refeeding there is no significant increase in the percentage of p-CREB-positive PRLH neurons in the ventrolateral medulla oblongota or in the dorsomedial hypothalamus suggesting impaired activation of these neurons

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:144729