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Phenotypes Associated with This Genotype
Genotype
MGI:3832410
Allelic
Composition
Prlhtm1Taon/Prlhtm1Taon
Genetic
Background
B6N.129X1-Prlhtm1Taon
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• become significantly heavier by 18 weeks of age when fed a normal chow diet ad libitum
• body weight gain is more prominent when fed a high fat diet ad libitum
• when food intake is restricted to match mean food intake of wild-type controls body weight is not significantly different from wild-type controls
• adult onset obesity
• become significantly heavier when fed a high fat diet compared to wild-type controls

adipose tissue
• increase in both subcutaneous and intraabdominal fat pad masses
• epididymal adipocytes are increased in size

behavior/neurological
N
• no significant difference in home cage activity levels compared to wild-type controls
• seen on both normal chow and high fat diets
• seen at 24 weeks of age but not before 14 weeks of age
• impairment in reduction in food intake following peripheral or central leptin administration
• feeding after a fast is increased at 14 weeks of age

homeostasis/metabolism
N
• no significant difference in oxygen consumption or mean respiratory exchange ratios compared to wild-type controls
• become significantly heavier when fed a high fat diet compared to wild-type controls
• in mice fed a normal chow diet ad libitum
• when food intake is restricted to match mean food intake of wild-type controls glucose tolerance is similar to wild-type controls
• in mice fed a normal chow diet ad libitum
• when food intake is restricted to match mean food intake of wild-type controls insulin sensitivity is similar to wild-type controls
• increase in hepatic triglyceride levels

liver/biliary system
• increase in hepatic triglyceride levels

nervous system
• after refeeding there is no significant increase in the percentage of p-CREB-positive PRLH neurons in the ventrolateral medulla oblongota or in the dorsomedial hypothalamus suggesting impaired activation of these neurons

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:144729


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory