Mouse Genome Informatics
cn
    Ldb3tm4Chen/Ldb3tm4Chen
Myl2tm1(cre)Krc/Myl2+

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• all die between 16 and 23 weeks of age

cardiovascular system
• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen
• however M-lines are relatively normal
• enlarged left and right ventricles
• the ratios of heart weight to body weight and heart weight to tibia bone length are increased
• thinner at end diastole compared to controls
• enlarged with a thinner wall
• increase in left ventricle size is seen in mice at 2 - 4 months of age but not at 1 month of age
• significant increase in left ventricular dimension at end diastole and end systole
• enlarged with a thinner wall
• in both the left and right ventricles
• electrocardiography reveals an atrioventricular block

muscle
• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen
• however M-lines are relatively normal

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Dilated, 1C; CMD1C 601493 J:144739