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Phenotypes Associated with This Genotype
Genotype
MGI:3832389
Allelic
Composition
Ldb3tm4Chen/Ldb3tm4Chen
Myl2tm1(cre)Krc/Myl2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldb3tm4Chen mutation (0 available); any Ldb3 mutation (24 available)
Myl2tm1(cre)Krc mutation (1 available); any Myl2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all die between 16 and 23 weeks of age

cardiovascular system
• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen
• however M-lines are relatively normal
• enlarged left and right ventricles
• the ratios of heart weight to body weight and heart weight to tibia bone length are increased
• thinner at end diastole compared to controls
• enlarged with a thinner wall
• increase in left ventricle size is seen in mice at 2 - 4 months of age but not at 1 month of age
• significant increase in left ventricular dimension at end diastole and end systole
• enlarged with a thinner wall
• in both the left and right ventricles
• electrocardiography reveals an atrioventricular block

muscle
• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen
• however M-lines are relatively normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory