Phenotypes Associated with This Genotype

Genotype
MGI:3832324

• Allelic Composition: Slc6a3^tm2(tTA)Xz/Slc6a3^tm3(tetO)Xz
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal action potential ( J:144671 )

• doxycyclin-treated mice exhibit increased overall firing rate of dopamine neurons with a high prevalence of neurons firing at rates greater than 4 Hz compared to non-treated mice

• doxycyclin-treated mice exhibit higher non-bursting firing rates than in non-treated mice

• however, burst quantity and characteristics are the same regardless of doxycyclin treatment

behavior/neurological

abnormal behavior ( J:144671 )

• doxycyclin-treated mice exhibit more lever pressing when food deprived than wild-type mice or untreated mice

• in a choice condition, doxycycline-treated mice exhibit increased lever pressing compared to wild-type mice or untreated mice

• however, in a no-choice condition mice exhibit the same amount of lever pressing as in wild-type or non-treated mice, and learning is normal

homeostasis/metabolism

increased dopamine level ( J:144671 )

• doxycyclin-treated mice exhibit reduced dopamine clearance rates compared to in wild-type mice