Phenotypes Associated with This Genotype

Genotype
MGI:3831893

• Allelic Composition: Cdh23^ahl/Cdh23^ahl; mt-Tr^m1
• Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:67312 )

• average ABR threshold is significantly increased by 3 months of age

increased susceptibility to age-related hearing loss ( J:67312 )

• the presence of this mitochondrial sequence polymorphism in mice homozygous for the ahl allele results in age related hearing loss by 3 months of age, which is absent when the CAST/Ei mitochondrial sequence is instead present