Phenotypes Associated with This Genotype

Genotype
MGI:3831869

• Allelic Composition: Cnr1^tm1Dgen/Cnr1^tm1Dgen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:143885 )

N • quinpirole-induced depression of inhibitory postsynaptic currents is normal

N • induced long-term depression of inhibitory postsynaptic currents (I-LTD) induced by 10 Hz stimulation with 10 um cocaine is normal

reduced long-term depression ( J:144773 )

• stimulation by 10 Hz, for 5 minutes plus 3 um cocaine failed to induced long-term depression of inhibitory postsynaptic currents (I-LTD) in dopaminergic neurons from the ventral tegmental area unlike in wild-type mice