Phenotypes Associated with This Genotype

Genotype
MGI:3831752

• Allelic Composition: Myoz1^tm1Eno/Myoz1^tm1Eno
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:144597 )

muscle

abnormal skeletal muscle morphology ( J:144597 )

abnormal gastrocnemius morphology ( J:144597 )

• cross sectional area of gastrocnemius is reduced

decreased gastrocnemius weight ( J:144597 )

• gastrocnemius muscle (fast twitch) weight reduced 24.4%

• soleus muscle (slow twitch) similar in weight to controls

decreased skeletal muscle fiber size ( J:144597 )

• type IIb fibers (fast twitch) in gastrocnemius are increased in number but substantially reduced in size

increased skeletal muscle fiber diameter ( J:144597 )

• type I fibers with a greater cross-sectional area

abnormal skeletal muscle fiber type ratio ( J:144597 )

• 56.2% increase in type IIa fibers in gastrocnemius (oxidative fibers)

• type IIb fibers (fast twitch) in gastrocnemius are increased in number but substantially reduced in size

• soleus muscle with a 68.1% increase in the number of type I fibers

muscle degeneration ( J:144597 )

• less degenerated tissue after unilateral cardiotoxin injection into the tibialis anterior

abnormal muscle physiology ( J:144597 )

• diaphragm muscle shows an increased resistance to fatigue

enhanced skeletal muscle regeneration ( J:144597 )

• improved regeneration after unilateral cardiotoxin injection into the tibialis anterior

• regeneration as early as 4 days after experimental treatment

abnormal muscle tone ( J:144597 )

• diaphragm muscle develops greater tension than controls after tetanic stimulation

homeostasis/metabolism

enhanced exercise endurance ( J:144597 )

• display extended endurance when forced to run to exhaustion on a treadmill

limbs/digits/tail

abnormal gastrocnemius morphology ( J:144597 )

• cross sectional area of gastrocnemius is reduced

decreased gastrocnemius weight ( J:144597 )

• gastrocnemius muscle (fast twitch) weight reduced 24.4%

• soleus muscle (slow twitch) similar in weight to controls