Phenotypes Associated with This Genotype

Genotype
MGI:3831703

• Allelic Composition: Hdac3^tm1.1Eno/Hdac3^tm1.1Eno; Tg(Myh6-cre)2182Mds/?
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased heart weight ( J:144604 )

• 72% increase in heart weight/body weight ratio by 12 weeks of age

cardiac hypertrophy ( J:144604 )

• signs of cardiac hypertrophy by 4 weeks of age

• hypertrophy exacerbated by 12 weeks of age

• both right and left atria are enlarged

• cardiomyocyte hypertrophy, particularly in the left ventricle free wall and the septum

mortality/aging

premature death ( J:144604 )

• significant lethality between 12 and 14 weeks of age

• 100% lethality by 16 weeks

cardiovascular system

cardiovascular system phenotype ( J:144604 )

N • normal sinus rhythm

increased cardiac muscle triglyceride level ( J:144604 )

• fasting myocardial triglycerides are increased after 24 hours

abnormal heart morphology ( J:144604 )

abnormal myocardial fiber mitochondrial morphology ( J:144604 )

• lack normal association with sarcomeres in cardiac muscle

abnormal heart size ( J:144604 )

increased heart weight ( J:144604 )

• 72% increase in heart weight/body weight ratio by 12 weeks of age

cardiac hypertrophy ( J:144604 )

• signs of cardiac hypertrophy by 4 weeks of age

• hypertrophy exacerbated by 12 weeks of age

• both right and left atria are enlarged

• cardiomyocyte hypertrophy, particularly in the left ventricle free wall and the septum

dilated heart left ventricle ( J:144604 )

• increased in both systole and diastole

cardiac interstitial fibrosis ( J:144604 )

decreased ventricle muscle contractility ( J:144604 )

• reduced fractional shortening of the left ventricle

cellular

abnormal myocardial fiber mitochondrial morphology ( J:144604 )

• lack normal association with sarcomeres in cardiac muscle

cardiac interstitial fibrosis ( J:144604 )

abnormal mitochondrial crista morphology ( J:144604 )

• reduced density of cristae

abnormal cellular respiration ( J:144604 )

• 25% reduction in complex I activity

• 39% reduction in NADH oxidase activity

• two fold increase in free radical production

homeostasis/metabolism

abnormal lipid level ( J:144604 )

• accumulation of neutral lipids in ventricles but not atria

increased cardiac muscle triglyceride level ( J:144604 )

• fasting myocardial triglycerides are increased after 24 hours

muscle

increased cardiac muscle triglyceride level ( J:144604 )

• fasting myocardial triglycerides are increased after 24 hours

abnormal myocardial fiber mitochondrial morphology ( J:144604 )

• lack normal association with sarcomeres in cardiac muscle

decreased ventricle muscle contractility ( J:144604 )

• reduced fractional shortening of the left ventricle