Phenotypes Associated with This Genotype

Genotype
MGI:3831675

• Allelic Composition: Tph1^tm2Lex/Tph1^tm2Lex; Tph2^tm1Lex/Tph2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal emotion/affect behavior ( J:144582 )

• mice exhibit less immobility and more struggling in a forced swim experiment compared to wild-type mice

• mice exhibit increased immobility in a tail suspension test compared to wild-type mice

abnormal response to novel object ( J:144582 )

• mice burry more marbles in a novelty-induced digging assay compared to wild-type mice

decreased thermal nociceptive threshold ( J:144582 )

growth/size/body

decreased body weight ( J:144582 )

• in males

decreased body length ( J:144582 )

• in males

homeostasis/metabolism

decreased serotonin level ( J:144582 )

• serotonin levels are reduced in the brain from 94% (cerebellum) to 99% (cortex) compared to in wild-type mice

• serotonin levels in peripheral tissues are decreased compared to in wild-type mice

adipose tissue

decreased percent body fat/body weight ( J:144582 )

• in males and females