Phenotypes for Brca2 Tg(Lck-cre)548Jxm Trp53 MGI:3831545 MGI Mouse

immune system phenotype ( J:79697 )

N	• proliferating T cells fail to exhibit the same increase in spontaneous apoptosis observed in Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm mice

increased activated T cell number ( J:79697 )

• likely due to decreased apoptosis

increased tumor incidence ( J:79697 )

• tumorigenesis is accelerated compared to in wild-type and Trp53^tm1Brd/Trp53^tm1Brd Tg(Lck-cre)548Jxm mice but not compared to in Trp53^tm1Brd homozygotes

increased lymphoma incidence ( J:79697 )

• 90% of mice succumb to T-cell lymphomas compared to 70% of Trp53^tm1Brd/Trp53^tm1Brd Tg(Lck-cre)548Jxm mice

increased malignant tumor incidence ( J:79697 )

• mice develop high grade malignancies

increased osteosarcoma incidence ( J:79697 )

abnormal chromosome morphology ( J:79697 )

• T cells exhibit increased frequencies of chromatid or chromosomal breaks, tri-radial structures, and chromosomal fragments compared to in Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm mice or wild-type cells

decreased cellular sensitivity to ionizing radiation induced cell death ( J:79697 )

• thymocytes are resistant to ionizing radiation-induced cell death unlike wild-type cells

• however, response to UV- or methyl methane sulfonate-induced cell death is normal