Phenotypes Associated with This Genotype

Genotype
MGI:3831544

• Allelic Composition: Brca2^tm1Mak/Brca2^tm2Mak; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:79697 )

N • T cell development and proliferation are normal

increased T cell apoptosis ( J:79697 )

• proliferating T cells exhibit increased spontaneous apoptosis compared to wild-type cells

• however, apoptosis of activated T cells following exposure to ionizing radiation, adriamycin or FasL is normal

neoplasm

neoplasm ( J:79697 )

N • mice do not develop tumors

cellular

cellular phenotype ( J:79697 )

N • response to DNA damaging agents is normal

abnormal chromosome morphology ( J:79697 )

• T cells exhibit increased frequencies of chromatid or chromosomal breaks, tri-radial structures, and chromosomal fragments compared to in wild-type cells

aneuploidy ( J:79697 )

• 14.5% of T cells exhibit aneuploidy unlike wild-type cells

increased T cell apoptosis ( J:79697 )

• proliferating T cells exhibit increased spontaneous apoptosis compared to wild-type cells

• however, apoptosis of activated T cells following exposure to ionizing radiation, adriamycin or FasL is normal

hematopoietic system

increased T cell apoptosis ( J:79697 )

• proliferating T cells exhibit increased spontaneous apoptosis compared to wild-type cells

• however, apoptosis of activated T cells following exposure to ionizing radiation, adriamycin or FasL is normal