Phenotypes for Trp53 MGI:3831429 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Trp53^tm1.1Brn/Trp53^tm1.1Brn
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:73028 )

• mice exhibit a similar increase in tumor incidence with the same spectrum as in other Trp53 null mice

decreased tumor latency ( J:73028 )

• median tumor-free survival is 116 days compared to 515 in heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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